1. Take all points off Charisma(The other stats are MUCH more useful)
2. Immediately max Intelligence at start(The higher your intelligence the more skill points you get each level, best to take advantage of this ASAP)
3. Don't max out any other attribute past 9 because you will be able to get an implant for each individual stat that boosts each by 1.
4. Make sure your Endurance is at 9
5. Don't take perks like 'Here and Now' and 'Fast Learner'. These essentially just rob you of a perk and make you level faster. There is no point in doing so because you will get to that level eventually anyway! Better to get to lvl 35 in 2 weeks then waste 2 perks just to save 4 hours.
6. Make sure your face and all is how you want it because there is no plastic surgeon, only 1 barber.
Think out your skill points and perks carefully and you will be awesome.