Okay, so, I've just started playing Fallout 3 again after a long time. Went to nexus, downloaded lots of mods (mostly just textures and gameplay changes). Anyways, I've hit an issue that I never had before when I played the game a few years ago. Occasionally, and seemingly consistently, the controls will freeze completely during a conversation with an NPC. Mouse will stop responding and keyboard won't do anything. I've tried alt-tabbing out and back into the game, and all that does is get the game stuck in the esc menu (though the mouse cursor has repositioned itself in the game to where I have the cursor on my desktop when I go back). Does anyone know how to fix this?

My load order:

Fallout3.esm
FakePatch_v1.5.0.22c.ESM
Anchorage.esm
ThePitt.esm
BrokenSteel.esm
PointLookout.esm
Zeta.esm
Unofficial Fallout 3 Patch.esm
Unofficial Fallout 3 Patch - Operation Anchorage.esp
Unofficial Fallout 3 Patch - The Pitt.esp
Unofficial Fallout 3 Patch - Broken Steel.esp
Unofficial Fallout 3 Patch - Point Lookout.esp
Unofficial Fallout 3 Patch - Mothership Zeta.esp
GW71-Anchorage.esp
GW71-ThePitt.esp
GW71-PointLookout.esp
GW71-Zeta.esp
MZWastelandTeleportShaderFix.esp
2-Handed-Melee-Knockdown.esp
2-Handed-Melee-Knockdown Point Lookout.esp
2-Handed-Melee-Knockdown Broken Steel.esp
Timescale 8.esp
FireLightFix.esp
DarNifiedUIF3.esp
Starke's Classic AP and Weight Restore.esp
colacollector.esp
empty container fix.esp
doctorli_glasses.esp
Echo_UseBothGloves.esp
EMPVision.esp
Destructibles.esp
Down'n'Dirty.esp
knockdowns.esp
ek.BrokenSteel.esp
FallDamage101.esp
Explosive Explosives v1.3.esp
BlankJournals.esp
FOSEPerception Distance.esp
Penetrating Lasers.esp
LongerDeathCamera.esp
Smurf_Impact_RealPhysics_FlyAway.esp
krzymar-MoonSize_080%.esp
Miscellaneous Items Fix.esp
royphilipsevil.esp
pater_NoTrace.esp
IncreasedDrinkingRadiation.esp
ShellRain.esp
Ice Cold Nuka, Converted.esp
GaussRifleRepairFix.esp
MMMs-NoAutoAim.esp
GauntletFix.esp
VATS Normal Weapon Degradation.esp
TAG.esp
ReducedUndiscoveredCompass(kalniel).esp
Blue Laser Protectron's Gaze.esp
NPC Height Randomizer.esp
GalaxyNewsRadio100[M].esp
RealFragGrenade3.esp
AddEmptyNukaBottle.esp
Burnification.esp
FleshBurningPlasma.esp
ACE2-1b.esp
GeneratorSound.esp
Triage.esp
HI Sound Fix.esp
Responsive Kill Reactions.esp
dD-Less Blood Time.esp
dD-More Gore.esp
dD-More Gore-PointLookout.esp
dD-More Gore-BrokenSteel.esp
dD-More Gore-The Pitt.esp
dD-More Gore-Zeta.esp
Powered Muscle - Base + Anchorage.esp
Powered Muscle - Pitt.esp
Powered Muscle - Broken Steel.esp
Fellout-Full.esp
Fellout-Anchorage.esp
Fellout-BrokenSteel.esp
Fellout-PointLookout.esp
Fellout-Zeta.esp

Obviously, with some of the mods, I've got FOSE running. I've also used CFF Explorer to make Fallout 3 run with the ability to use more than 2gigs ram. I've also used FO3Edit to observe conflicts and fix those that need it.

I've also used the conflict detector and load order report function of FOMM to properly arrange the mods in the right loading order (for those that have that info in them, at least).

This is seriously game-breaking, and I have no idea what's causing it.

I've also edited the INI file with the BSA Manager to load all of the .bsa packages. I was getting red triangles and found out that would fix it.

shake the spot

Holy crap that's a lot of help. Thanks, man.

I followed the instructions about cleaning all the mod files, but I found the rest to be unnecessary for me.

Using the simple process of elimination (a pain in the ass to do with an issue that can take up to 5 minutes to show itself), I figured out it was the Galaxy News Radio mod that adds 100 new track slots. Though, that technically isn't true, either. It was the bloody music track files that went along with it. Apparently Fallout 3 hates .mp3 files.....I deleted all those and extracted the .wav files instead, problem solved.

Oi, modding can be a pain in the ass sometimes, no?