To state it simply I'd like to know what its like to be the NPC in the Fallout games. Having to worry about keeping the bar supplied, maybe arguing with another player over the price of whiskey they're trying to sell me and haggling, hiring a bouncer to deal with the bad eggs. The whiskey dealer has to go and loot, but since his skills would be more towards inter-personal than anti-personal he'd need people to escort him. The raiders outside the towns could live off of the player formed caravans.
The military situation should make sense though. I think the game would not be fun if everyone was overpowered and if guns and fighting are that commonplace. People who are more oriented towards combat could have shifting SPECIAL values based on the types of engagements, armor, weapons, or fighting styles they used. They should not be able to collect resources though, to balance out the need for an economic base.
People who are more oriented towards economic action should be the ones able to loot, craft, sell items, own property, with the exception that they can't use weapons. Maybe this would force something similar to capitalism to occur in the game, small corporations of individuals who would use their money to pay the subsistence of an armed class to protect and expand upon that property.
After all, most groups/factions/whatever in the lore are protecting the trade or trying to take over areas of it, without the traders there's no use to a town since no one gets paid.
I think the game should reward specialized jobs, or people who create something rather than just making us the perpetual destroyers of each other and the game world, supplied by NPCs who don't voice realistic concerns as to what's going on. It'd be interesting to be any possible role in the fallout universe, even one you invent.
I want to sell crispy iguanas-on-a-stick, will it be possible?