I get also a crash to desktop at a certain point in the single player campaign (save point "72 Power Out"). Summary from the event log:
Faulting application name: Crysis2.exe, version: 1.2.0.0, time stamp: 0x00000000
Faulting module name: Crysis2.exe, version: 1.2.0.0, time stamp: 0x00000000
Exception code: 0xc0000005
Fault offset: 0x008e549f
The crash occurs after the short sequence of entering an alien spear and then making it with a jump onto a vtol. Then it shows a short video sequence explaining the derailed train and that I have to meet at the Prism, and then crash. On another crash I just played the sequence once more, but here it always crashes (perhaps because its in a fixed scripted sequence).
Right now I can't continue the single player campaign. What should I do?
Edit: Some searching with google shows I am not alone. Another user gets a crash at exactly the same location in the single player campaign. It's documented with screens here: http://www.overclock.net/pc-games/982936-need-help-crysis-2-bad.html