The issue: Crysis 2 causes my monitor to lose signal. This can happen anywhere from 30 seconds to 1 hour into gameplay. This has never happened with any of my other games.

This problem first arose during my second play-through, after downloading an NVIDIA Physx driver pack for another game. My GPU setup is AMD, so I scrubbed out the NVIDIA drivers thinking they were conflicting with AMD drivers, but the issue persisted. Yesterday, I did a clean install of Windows 7 64 bit. I fully expected Crysis 2 to work again (it worked fine for the first 2-3 weeks), but not 2 minutes into a new play-though, my monitor loses signal. Unbelievable!

If anybody has any insights or has experienced a similar issue, I'd love to hear about it. Thank you

Sys. specs:

Windows 7 Home Premium 64bit
Intel Core 2 Quad Q9300 @ 3.0 ghz
Gigabyte GA-EP45T-USB3
Gigabyte Radeon HD6850 CF
8 gb Kingston HyperX SDRAM DDR3 1600 (1333)
Ultra x4 1050watt PSU
Samsung SyncMaster P2570HD Monitor

*edited* I have tried running Crysis 2 with both my Crossfire setup and with just 1 6850. Doesn't make a difference.