The problems:
Melissa not showing up at the camp, despite there not being any reason for her not to be there.
Colonel Moore dialogue not updating.
Papa dialogue not updating.
Female chemist (I forget her name - one of he advisors) wants proof, but doing what she requires doesn't update her part of the quest.
I figure what has happened is that because I decided to do a lot of exploring before tackling the main quest line, maybe my earlier interactions (the majority of which are only partaking in conversation) with a few of the quest NPCs threw everything into chaos. If that's the case, it kinda goes against the whole point of having an open world environment.