- Enclave forces at Mariposa military base are forced out by Super Mutants
- The headquarters of the Enclave are destroyed when the Poseidon Oil Rig is nuked by the Chosen One
- West coast Enclave forces are forced out of Navarro and hunted down or integrated into NCR
- The remainder of the Enclave at Navarro and the Oil Rig relocate to Raven Rock under Autumn Senior
- Raven Rock is destroyed and the remaining Enclave forces relocate to Adams AFB
- Adams AFB is nuked by the Lone Wanderer and then overrun by the Lyon's Brotherhood of Steel
- The last known Remnants of the Enclave at Navarro die fighting alongside the Courier at Hoover Dam
The Enclave have suffered many defeats throughout the wasteland. And since their emergence have been forced to relocate twice, due to the destruction of three major headquarters. Any known remaining outposts have been overrun by local forces, and the last known remnants of the Enclave, with the exception of a single Eyebot, are all dead. This is of course assuming that the Courier completes For Auld Lang Syne, and that the Lone Wanderer decided against nuking the Pentagon in Fallout 3. Which is not at all a stretch, all things considered. A post-war faction simply can't survive the destruction of three headquarters, especially when most defeated outposts have been completely overrun. Expecting any sort of meaningful return of the Enclave is ridiculous.