What is the easiest/best way to kill Nightkin?

In my experience, weapons with a high DPS rating are usually best, even if they are inaccurate. Also, I think that nightkin typically don't wear armor, so if you have hollow point bullets, those also help.

I think a 9mm SMG with the light bolt mod and hollow point bullets made short work of them for me.

I was a bit low on ammo, so I actually used the repeater on 'em. Basically, the key to what I did was charge against them and sidestep when they start to swing; you can usually dodge the blow and give yourself a second or two to line up some shots. By using rapid fire and moving enough, they aren't too bad.

A related strategy is to set up frag mines to cripple their legs and kite them.

Silly post frequency limit...


I just shotgun them. Run up, shotgun, backpedal to dodge, repeat. I have to keep moving around though, as I'll quickly back against a wall when doing this. I usually only get hit 1 out of 5 swings when I do this.

All the nightkin I have taken down, I have done with there own weapon of choice, the rebar club.
Run up to em and start swinging, and hope they run out of hp before I do, hard on the stimpak stock pile some times.
The rebar club is pretty good. I am still lugging one around for when I dont want to waste ammo.

10mm pistol worked fine and fast for me.

hit vats ... spam 5 uppercuts ... usually explodes by 3rd hit (bladded gauntlet, obtained from NCR`s rehabilitation center's admin's building inside the ringleader's desk). I need something better for deathclaws but so far Unarmed is kicking-it OP for me.

Would setting them on fire work?

Dynamite

Stealth boy, sneak, throw dynamite, malicious grin

One word.

Veronica.

Make your first aimed shots of whatever you are using at their legs or one leg. Cripple them and they will just limp slowly at you. Stand back and repeatedly shoot them in the head with your weapon of choice.