Have you tried searching for one of the thousand other posts on this topic? There is quite a lot of information on this out there, many fixes, and much wrong info.
It could be too many mods. You might need a specific mod. Could be audio drivers. Could be your power supply. Could be a windows update screwed your pooch.
Seriously, look around in some of the related forums around here. I have made the same suggestions to people 3 times today and don't feel like repeating myself, but don't want to leave you hanging.