I go with a stat setup like this.
S. 8
P. 5
E. 9
C. 1
I. 5
A. 6
L. 6
I max Strength and Endurance with bobbleheads and the "ant injection"
It isn't the most overpowering game breaking build but is the funnest one I have ever played. It isn't all that hard, and is quite satisfying. I love sneaking up on some raiders and dropping a frag in the middle of them, or laying mines throughout a complex and leading enemies through it. And of course there is the simple sneaking up and slashing them apart one by one. :ninja: