The biggest difficulties with this would be 1) implimenting these changes, requiring a mroe adaptable system, where you and the world around you change with your stats. 2) Eplaining this to the player. there's a dozen and a half skills that these would have an effect on, and there are seven skills that could alter all of those with every change. (this might be fixed with a more interactive set up process that simply showed what each S.P.E.C.I.A.L. would change)
So is this something that is pheasable, that being, can it be done and would players be able to understand what was going on with each change, and if it was, would you want to see it in a Fallout game (future, DLC, MOD)?