Anyone with half a brain would choose skilled, 10% less XP is nothing comapred to the skill boost, I also took Hot Blooded, I have a short temper myself and I think at 50% health a beserk mode would be useful.
Do you even NEED those skill points to max out skills?
No, Skilled is quite useless. The other perks offer you a once-in-a-lifetime chance to increase your firing speed, accuracy, melee damage, carrying weight, crit etc.