So I bought FO3 when it first launched, played it a bunch (unmodded) and haven't touched it since. I'm feeling the urge to give it another shot, this time with New Vegas installed, but i'm confused about which mods I should be searching for. There's a nexus for both games. Will mods designed to work with the vanilla game not work at all if New Vegas is installed? Or will they just not work in relation to New Vegas content? From memory, in Oblivion you could still use weapons or game zones that only existed in the vanilla area while also running the expansions, but I could be wrong.

I would appreciate a little clarification before I spend hours hunting down the right combination of mods.

Thanks.

New Vegas is 100% its own game. It is in no way relayed (save for universe and a robot) to Fallout 3.

Most mods for Fallout 3 are not directly compatible with New Vegas.