There are reasons I've always done manual saves like every 10 minutes in gamesas games (Morrowind, Obliv, FO3, etc).....
DITTOS.
I' learned to do that with Oblivion.
DO NOT RELY ON AUTOSAVE with these games. Yeah, I know it svcks but it is true.
No issues yet here with saves (knock on wood) but I use manual saves as quoted above though I don't alway save so often..it varies though. About 18 plus hours of real time game play so far with FNV.
I rotate about 5 saves that I overwrite as I proceed and make 'key ' saves that I keep around to fall back on in case of corruption of the rotated saves that
can not be recovered from. (Fallout 3 lesson that modders learn).
I turn off auto save entirely. I tihnk it causes more issues than not.
With FNV I dont' have near as many crashes as Fallout 3. It has been stable for me (so far).
With Fallout 3 I was paranoid about saving all the time due to its crashiness.
FNV , for me, has not caused that fear to erupt....yet.
So , just say no to autosave people and yes, Beth deserves a B i t ch slap for failing to properly test.