Now it might require a few a tweaks to the backstory, seeing how all of the Vaults are in the US (and at most North America).
But if the story can be worked out, I would like to see the next game set in a jungle although mutated by radiation. Candidates are the Amazon and the Congo!
Think about all the new creatures we could fight!
In the Amazon we could have mutated vampire bats and even bigger anacondas! As for the Congo,... intelligent... apes.
Now I know there will be some issues seeing how transitioning from a flat sparse desert to a dense tropical region require new tactics.
But I want to see what you think of the idea.