I am at work, doing what I often do at work; think about Fallout. So, if I seem lazy for not trying this myself, I'm not, I'm just otherwise occupied.
So I was thinking, Implant GRX, Hunting Shotgun w/modified choke and a fistfull of dynamite could make for some potentially interesting post apocalyptic sport. With Implant GRX throw objects are affected by in game physics, and therefore are also slowed. With Quick Draw, the courier could potentially shoulder a weapon and take aim at a flying stick of dynamite he had just thrown making for some interesting aerial detonations. Paired with splash damage, it could make for a fun, if stupid, new way to take out enemies.
I'm not sure, but if you can Target your own projectiles in VATS, that could be an alternative method for the less twitchy players.