There are plenty of differing approaches to this. I 'pause' the Main Quest very early via any one of several imagination exercises, then go off to explore and get stronger. If I come back to the MQ it is much later, and completing it is a good way to ease your character into retirement.
If you have never done the MQ, it is fun to do at least once. I often pretty much ignore it now though and focus more on roleplaying and the open world for exploring and wanderin' around. :foodndrink: