suggest a better dungeon for me to loot and level up since i'm only making 1-2 thousand a trip.
http://uesp.net/wiki/Oblivion:Rockmilk_Cave
edit: Yes, you can make a profit during the main quest. Loot everything valuable that your pack will physically allow you to, then sell it. It's the same as usual.
If you mean expensive artifacts you get as rewards, then I can't help you there. I can't remember any specific loot tables.