They're all jerks. I always kill butch before leaving the vault (or anyone else that gets in my way). And kill everyone else during Trouble on the Homefront.

Let me put saving the wasteland on hold so I can help you jerks, and then these ungrateful [censored]s don't even thank me

I think they got it quite right. In previous Fallouts vault dwellers have been the same: ignorant, ungrateful and vocal.
Cmon, they've been living under a rock for 200 years. They are used to the propaganda and lies the Overseers have been feeding them up with. If you throw a vault dweller into the wasteland, he won't survive (you see this if you sabotage V101). The vault is the only world they know and only world they care about. They strongly believe that nothing lives outside the vault.

They are just stock. Basically just human material for the Enclave who organized the vault system. The vault dwellers were never intended to be strong humans ready to resettle the wasteland. They are just stock ready to be killed in experimentation. The Overseer says it himself: Vault 101's purpose was similar to that of Vault 13 - be a reserve of pure human stock if the Enclave ever needs some extra bodies for war and further experimentation.

You should feel sorry for them.

I like Andy and Butch (dragons!) but the rest of them can go die in a hole. Wait, they're already in a hole. That's convenient.

The only person I cant stand is the Overseer and that idiot whose banging on the glass when you are leaving the vault

Of course that comes from my Enclave bias, but I respect the Overseer's obsession of human genetic purity - the real reason he doesn't like you.

Genetic purity is a lame goal when you consider how all living things mutate over time. If the human ancestors hadn't mutated at some point and lost their "original" genetic purity then humans wouldn't exist, and then where would those Enclave [censored] be? Crawling around in trees, going "oohh, ohh, ohh", and hurling fecal matter after one another? I don't know, maybe it's my anti-Enclave bias, but I don't respect people obsessed with genetic purity any more than I respect real-world humans obsessed with racial purity.

Humans are humans, regardless of the color, regardless of minor mutations or gene damage. People who think otherwise can go to hell, and I'd generally be happy to lend them a hand getting there. Obviously this applies to all groups, including the minorities, so Magneto, the Tenpenny-ghouls, and other such [censored] can burn along with the KKK, the Enclave, and all the other bigots, for all I care.

Anyways, I'm digressing. Point is that I hate bigoted people who dislike me for the wrong reasons. Don't hate me because my dad had brown eyes, dark brown hair, and a big nose. Hate me because I'm a bit of a [censored] at times, or because I simply rub you the wrong way, or because I'm approaching sociopath-levels of empathy towards people I decide that I don't like, or because I don't always know when to shut up. All those are valid reasons but please, don't hate me because my "race" isn't "pure". That's just mindless garbage.

Consequently of the above, I really want to stuff a shutgun up the nose of that overseer and dare him to insult me, or my father, just one more time. Obviously I also want to introduce that guy who bangs on his window in the beginning to a sledgehammer as well. Or better yet, tie him up and pour miniature fire ants into his pants. I suppose that requires waiting for Lesko to actually invent the damn things, though. Darn.

Butch gets a nasty dose of reality by ending up as a pansy hairdresser and eventually runs off to some bar deep into the hull of an old carrier, which as it happens is probably the most vault-like safe place around. And there he can get drunk while telling stories about how bad ass he was as a Tunnel Worm to people who have actually survived slavers and raiders and whatnot out in the real world. Thus he'll be the laughing stock of everybody and his only real skill is to be a hairdresser, which further undermines any claims he might make of being badass. That's poetic justice at its finest, isn't it?

Amata, your childhood friend who thanks you for saving her bony little ass by permanently kicking you out? Mostly a stupid brahmin, IMO, but then I suppose she's got little choice if she wants to actually remain in control. Gotta cry with the wolves you're among, as an old Danish saying goes. Which I suppose is a different way of saying that the majority of the Vault 101 dwellers are ignorant dumb[censored]s who really are mostly worthless at this point in time.

Then again, ignorance can be cured, so maybe there's hope for the people inside 101. Not like fear of the unknown isn't a part of human nature, just as much as being a complete bastard towards anything that isn't identified as being part of your own group. In that sense, I can mostly forgive the 101 dwellers. It's not directly their fault that long-time isolation has caused their perception of the world and humanity to become a garbled mess. Over time, exposure to the real world may rectify the problem.

By the way, I do apologize for my colored language. I'm under the impression that the sensor should catch most of it, but if anything overly excessive actually does manage to get through then I apologize in advance. I'm not an old lady nor am I religiously inspired to dislike strong language, and as a consequence I really have a hard time expressing deeply felt emotions in a PG-13 friendly manner.

I like the officer who preteds he didn't see you when you return, I forget his name.

EDIT: Black Spider I'd say human history would be evolution not mutation.