That's your opinion, and I, as well as quite a few others, disagree. I cannot play TES games with mods, only high res texture packs, which aren't really mods. I like the vanilla experience, the way Bethesda intended for it to be played.
But of coarse, that's just my opinion, and there's nothing wrong with mods. They just aren't for me.
On topic, no, there isn't a single thing I want to change yet.