I recently re-played FO3 and decided to use grenades more often and realized I have been ignoring something fun lol. So I am going into a NV playthrough using a character with a much bigger focus on explosives (never used anything besides Guns/Small Guns). So my question is, which is actually better? I really cannot tell a difference, besides damage, between the Grenade Rifle+ and the Grenade Launcher. What situations make one better than the other?

I generally sneak almost constantly and always go for sneak attacks than full-out assault. Sniping especially (usually using That Gun and Sniper Rifle++). I don't use uniques, they've never interested me lol.

http://fallout.wikia.com/wiki/Thump_Thump

I never really liked the look of Thump-Thump. I generally will choose what looks best rather than which is better when it comes to Unique weapons vs Base weapons.