They'd
probably be different for Skyrim, like "M'aiq's life is hard already. Why
would he want to make it any harder?" or something referencing absence of a hardcoe mode in Skyrim. It would be cool if some of his Skyrim lines referenced his lines from former TES games though.
Fun thread about predicted M'aiq quotes: http://www.gamesas.com/index.php?/topic/1234127-predict-maiqs-quotes-if-he-is-in-the-game/page__view__findpost__p__18677746
"Enchantment!" (Sandal in DAO)
"It's a secret to everybody." (Legend of Zelda)
"Brother/Sister, I do not spread rumors, I create them." (Lucien Lachance)
"It's only a model." (Holy Grail [about Alduin statue])