This is where we Address them. Post the weird little things that bother you, or possible explanations to someone else's bewilderment. As for my first few;
After drinking Black Coffee, why does it say, Coffee Cup Has Broken? Nothing similar pops up when you drink any other beverage, so does the Courier smash it over his head and scream "[censored] YEAH DADDY LOVES HIS MEDICINE" or something?
Is the Pip-Boy a TARDIS? Does it scan, breakdown to the molecular level, and then store our things inside of it, gaining weight proportional to the object and when we want something, we select it with the cursor and it materializes? That would actually be less stupid then having a Red Glare and Flamer in you pockets.
Who's the prewar scientist who said, "Hey, you know what would help the war effort? Giant Wasps and Splicing Rattlesnakes with Coyotes!" Furthermore, Who Greenlit this?
Why don't Chomps Lewis and company over at Sloan get the hell outta Dodge? No one can stop them. The NCR clearly doesn't care enough about them to ever give them protection so why would they feel loyal? What Do They Do All Day? There's 6 men and one woman, there HAS to be a clemitia outbreak Eventually. And most importantly, DEATHCLAWS.
I have more, but I wanna see what you guys think.