Can there even be a hybrid of them anyway lore wise?
http://www.uesp.net/wiki/Bloodmoon:Werewolf
"Living as both a werewolf and a vampire is tough, as the disadvantages of both add up. Travel and general interaction with people become pretty limited, for instance, and you take sun damage and must kill every night. The stat increases, however, are considerable." This was in Bloodmoon.
I like the idea of having both vamps and werewolves, adds a different play style and difficulty level. I've no idea what Twilight is, other than it is a book or a movie...some kinda story anyways (I'll guess its aimed at the younger generation since I do read and watch movies, but don't pay too much attention to the adolescent aimed stuff...I'm older so it just doesn't appeal to me),...no idea what the connection is to Elderscrolls, except it's brought up often. I've watched the underworld movies and enjoyed them well enough. But I don't see ES as having quite the same lore, except in the most basic concepts.
In past games I never want to play as a vamp on a first play through, but it does add to my gaming..I have to be paranoid around them and keep watching to verify I didn't contract the disease. I would go to one of the churches usually afterwards for the blessings..just in case.