My game gets screwy around 148-150 plugins as well. Although I get more than just textures screwing up. The "use" key will shut down as well. It's very odd, almost like you've walked into the twilight zone or something.
I was inside a cave when it started, and the rocky textures were switched by skin textures. Seeing eyes and noses on the walls and ground, coupled with Existence 2.0 playing on the Pip-Boy... yeah.