I have the steam version of New Vegas (as opposed to the retail version, if that makes a difference) and it is up to date as of today.

I have all the DLC, including Gun Runner's Arsenal and Courier's Stash.

I can start a new game just fine, but when I try to load a game, be it from the autosave or the manual save, the game load forever and if you Crtl Alt Del to the task manager it's listed as "Not Responding"

Is there anyway to fix this?

No one can even make a WAG, since you chose not to include adequate information.

Well theres not much more to say.

I guess you can have my specs

Intel i7 2600
8gb DDR3 Ram
2gb AMD 6970

Basic Hardware Specification Chart (Empty so far)

Processor Manufacturer: AMD / Intel
Processor Name / Type: Athlon X2 / Pentium D / C2D / dual core / quad, etc.
Processor Speed: ?.? Ghz
Operating System / Service Pack: WindowsXP with SP #?, Win7, Vista ?
System RAM: ? ? GBs (MBs, if less than 1024 ? )
Video (GPU) Manufacturer: ATI / Nvidia (only those two are supported, PERIOD, so please answer which of them you have)
Video Card Model: (examples) Radeon HD 6670 / Geforce GTS 450
Video Card Driver Version: Catalyst ?.? / Nforce ??.??
. . (please use the numbers, and dates, *not* the word "latest")
Video Card onboard RAM: ? ? ? MBs
Sound Card Manufacturer:
Sound Card Driver IDs:
Sound Card Model:

(And this is only for the raw hardware & driver variations. Potential software conflicts are far more likely to be game play problems, and developers cannot test for all possible program loads.)

Processor Manufacturer: Intel
Processor Name / Type: Intel i7 2600 Sandy Bridge /quad core
Processor Speed: 3.4 Ghz
Operating System: Windows 7
System RAM: 8 GBs
Video (GPU) Manufacturer: AMD
Video Card Model: (examples) Radeon HD 6970
Video Card Driver Version: Catalyst ?.?
Video Card onboard RAM: 2048 MBs
Sound Card Manufacturer: Asus P67 Mobo Onboard
Sound Card Driver IDs: N/A onboard soundcard
Sound Card Model: n/a

I only ever have just steam and the game .exe running while I play, rarely Internet explorer, only windows 7 necessary programs and Norton Anti-Virus running in background.

I'll find my Catalyst version later I'm in the middle of a TF2 game.

Catalyst Version 11.9.

Any help?

Can you start a new game then try to load a save?

Yes.

Has it ever worked (loading save files)?

Is Steam installed to the Program Files directory? If so, it is recommended to install outside of that directory due to access restrictions placed upon it.

Have you try going to the My Documents\My Games\FalloutNV\Saves ... directory and clearing all the files and attempting a fresh save. A corrupted save could cause similar problems.

I'm having a similar issue to yours. I started playing the game yesterday and did about 5 hours. and now when i try to start the game the loading screen will take forever and i will eventually have to access the task manager to close it,

Any solution to this issue ?

Start a new game and load your save file, only sometimes it resets your challenges.

I'm having the same problem I've been playing for 2 days and today it's just not working and the load screen freezes - not respond - grrrrrr! somebody help please

*Creating a newgame works fine for me but i'm already into the game with a level 10 who i enjoy i ho[e this narrows the problem.

This may help
http://www.gamesas.com/index.php?/topic/1208859-endless-loading-screen/page__view__findpost__p__18929113