Currently im playing on Normal. I remember how generic normal was in FO3 and I am just wanted a fairly leasure play through with some challenges. I kept hearing the changes such as DT and all that so I desided to start off with normal. I have to say some things are very challenging especially when you shooting at someone with good armor and you can hear the metallic THUMP as your round just bounces off.

When the BoS attacked me I was wearing upgraded metal armor and every time the Gauss rifle hit me you could hear the thump as my armor stopped most of the shot.

I do how ever once I get the hang of the game and doing everything such as the crafting at the camp fires and such I plan on playing on hard with hardcoe mode enabled.