So I've been playing for about 37 hours on this save with very minimal problems, no crashing, no extreme FPS drops, or anything. But then I started Honest Hearts... In Zion, it was more of the same, near perfect gameplay, and then out of nowhere, as I return to the Mojave, absolute destructive FPS drops everywhere I go, even interiors.

Here's my load order:
FalloutNV.esm
DeadMoney.esm
HonestHearts.esm
OldWorldBlues.esm
LonesomeRoad.esm
GunRunnersArsenal.esm
CaravanPack.esm
NVCE Main.esm
Advanced Recon Tech.esm
More Perks.esm
More Perks for Companions.esm
More Perks for Dead Money.esm
More Perks for Honest Hearts.esm
More Perks for Old World Blues.esm
NVInteriors_Core.esm
NVInteriors_WastelandEditon.esm
NVR-Strip.esm
Project Nevada - Core.esm
Project Nevada - Equipment.esm
New Vegas Error Corrections - DLC.esp
DarNifiedUINV.esp
CASM.esp
Readius_NV.esp
The Mod Configuration Menu.esp
populatedcasino-medium.esp
UHNV.esp
UHNV-Dead Money.esp
UHNV-Honest Hearts.esp
UHNV-OWB.esp
NVR-NPCs.esp
NVR-Version_10.esp
XFO - 2da - Bleedthrough - 10% (from 20).esp
XFO - 4ba - Perks - Perk Every Level.esp
XFO - 6aa - Epic Skills - Effects Over 100 (NVSE req).esp
XFO - 6be - Pacing - Vanilla (JUST No Cap).esp
Project Nevada - Cyberware.esp
Project Nevada - Dead Money.esp
Project Nevada - Honest Hearts.esp
Project Nevada - Old World Blues (No Cyberware).esp
More Perks Update.esp
More Perks for Companions Update.esp
More Perks for Dead Money Update.esp
More Perks for Honest Hearts Update.esp
More Perks for Old World Blues Update.esp
Advanced Recon Gear.esp
Advanced Recon Tech.esp
Advanced Recon Gear-Locations Doc Mitchell.esp
ADAM - MAIN.esp
ADAM - HH.esp
ADAM - LR.esp
ADAM - Rangers on Patrol.esp
ADAM - Outcast Ranger Armour.esp
Advanced Recon Gear - Project Nevada.esp
NVCE DLC01.esp
NVCE DLC02.esp
NVCE DLC03.esp
NVCE DLC04.esp
Faster Runing.esp
WeaponModsixpanded.esp
Project Nevada - WMX.esp
WMX-DeadMoney.esp
WMX-HonestHearts.esp
WMX-OldWorldBlues.esp
WMX-LonesomeRoad.esp
WMX-GunRunnersArsenal.esp
NVInteriors_Urban_Edition.esp
The Weapon Mod Menu.esp
ProjectRealityMkIv5HDR.esp
ELECTRO-CITY - Imaginator.esp
BetterGamePerformanceV4.esp
Imp's Timescale Adjuster.esp
Bashed Patch, 0.esp

Total active plugins: 72
Total plugins: 73

I tried to upload my save so that someone could look but MegaUpload wasn't working for me. I'll keep trying though.

Thanks!