The major gameplay aspect of every Fallout games since.... the first one, has been roughing it in the wastes, by yourself or in groups.
WAT
Bethesda... tried to tackle this problem in what I feel was the wrong way, changing the setting to somewhere much less Stable then Cali and setting up several places where it was worse.
However thematically the restoration of Society has made for some compelling stories, for example, I don't know about you, but I preferred New Vegas' Story over 3's even if it's exploration was more boring. This is mainly because it's engine was deseigned for F3 a game built around re discovering D.C.
So, I want a Fallout game that makes it's Gameplay fit with it's theme of rebuilding, as apposed to rediscovering, about founding a city, making allies, fending of raiders, setting up trade routes.
Anyway, this post is already to long for what I'm saying, Discuss, Flesh it out, tell me I'm an idiot, there's my two caps.