I have a similar build and feel that 2-handing seems to leave you susceptible to taking a lot of damage. (Sacrificing Def for Attack power I guess)
Are you using the block-jab thing to break/interrupt their attacks?
Also focus very heavily on your 2-H skill and try to time your power attacks for when theyre stunned or recovering from an attack of their own to do a tonne of extra damage. And Im not 100% on the game mechanics here but I found that whenever I was out of stamina near melee enemies, they would use a finishing move and 1-shot me.
Oh and you'll need a lot of stamina. I increased only stam until I had 150 and then alternated between stam and health without ever touching magicka.