I remember Bethesda talking about the whole Radiant Quest thing and how (this might have been a while ago) if the PC kills an inn keeper we might encounter the inn keeper's son arriving to fill his father's shoes.
I've been very curious because I'm playing a rather nasty PC and have had urges to purge a few settlements... but if that means I'll be left with an NPC-less zone then forget it.
Does anyone know how re-population works or *IF* it does?