Hi there I have a massive oblivion installation with UFCOM and hundred other mods, that does not work now. I cannot get wryebash to run either, all I can get is OBMM to load, I check all my mods, run obse and it crashes.

Same happens when I try to run oblivion vanilla. Also using the oblivion launcher, it does not let me edit the options or video card settings..

Going to need a bit more info here...did you uninstall/reinstall Oblivion in between going from XP to 7? Where is Oblivion currently installed on your HD? If you haven't reinstalled Oblivion in between your OS upgrades, that's the first thing I'd do. Back up your mods first but don't add them into the fresh vanilla install from the get-go. The first thing you need to do is get vanilla Oblivion working like it should.

Windows 7 also has a little bugbear called UAC (User Account Control) that tends to cause more problems than it solves with games, especially modded ones, that are installed to the C:\Program Files or C:\Program Files (x86) directories. When you reinstall, try installing Oblivion somewhere other than the default location (IE, Program Files). All my games are in a separate folder on my HD (C:\Games) for that reason.

When you reinstall you might also have to http://sites.google.com/site/oblivionpoinfo/troubleshooting/regenoblivionini, even if it's a "fresh" version of Oblivion. (I ran into that problem the last time I did a fresh reinstall--Oblivion kept crashing straight out of the box. Regenerating the .ini fixed it.)

Not sure why your options / settings would be greyed out in the launcher. That suggests to me that your install's been corrupted, but someone else might know better.

You can try that first before you destroy your game. If that not helps I suggest that you should read http://tesivpositive.animolious.com/?page=troubleshooting. :read:

There is absolutely no problem with Oblivion on Windows 7, 64 Bit (I do have Ultimate).
No need to turn UAC, Compatibility or whatsoever on/off.

The only thing you have to do is delete the old oblivion.ini, if you put an old ini there manually.
Oblivion runs on W7 like a charm, for best results, the obse is necessary with the fastexit2, and the osr dll.
everything else is your choice.
The massive FCOM installation is bugbear. it keeps doing CTDs, no matter what I do.
WyreBash comes with an all-in-one installtion exe since version 2.8x or 2.9x.
Really, be smart, do one mod after the other. technically there is no limit with W7.

additionally you might get the cff explorer and change the 4gb switch for the oblivion.exe.
but this was never a casue of a ctd on my rig. almost and only fcom and its disharmonies with other essential mods.

the basic installation should include the uop for olivion, shivering isles and the mods. plus the supplementary from arthmoor.
you should be safe with them anyway.