A few things that are really irritating and have ended up in the death of NPCs throughout my playthrough

There's a nip in the air, it won't be goo -dead-

I may not be the best black smith in whi... -dead-

I used to be one of the best soldiers in skyrim, until I took an arrow to the k... -dead-

These lines come from some of the most annoying NPCs in the game, at least in my opinion.

Unfortunately the third is quite common.

Really every NPC is annoying. They assume just because I'm standing near them that I want to talk and continually say "hm?" "what is it?" "Is there something I can do?" "out with it." "Yes?".

I feel like screaming "SHUT UP!!!" In their face..

Edit : Oh, and don't forget the staring. If they decide they want to not talk to me they will just have a blank stare on their face like they have never seen a Khajiit before...