2. Once you file the soul gem store it in your house. You won't need until your ready to use it for enchanting.
3. Buy a house, if you don't already have one. It's a great place to store items you may need for future trips.
4. You don't need 100lbs of potions. Most dungeons, caves, or forts are loaded with them and you replace them as you go.
5. Save often. I like to save before I open a door. Nothing svcks more than loosing the last one to two hours of game play because I got my tail kicked when I opened that door.
6. Be careful how much you load up your companion. They can die and you may not be able to take with you everything you stored on them. You can't fast travel over encumbered.
7. When looting bodies try and only take item of higher value. No point caring around 20 pairs of shoes worth one gold. Unless you have a thing for shoes.
To answer your question when I leave my house I'm around 120lbs. This includes around 200 arrows, one bow, a sword, light armor, and 50 health potions. My max carry is 345lbs. By the end of a dungeon I'm close to the max. Plus all the junk you can't remove from your inventory because they are quest items and you have not found that quest yet.