I'm running a 64bit system and I've installed the 1.9 patch, DX11 patch, and texture pack in that order. I restarted after each patch to ensure a good install. The DX11 features work but the high res texture button is grayed out. Also on start up the game says it doesn't support HD5800 series cards. I was thinking this may be the problem but am unsure as i don't have another GPUs to test it on. I've looked all over the internet and can't find anything on someone having this problem with a 64bit system.
SpecsXFX HD 5850 running 11.6 drivers
Phenom 9600
MSI K9A2 Platinum V2
4GB DDR800 RAM
Vista 64bit Home Premium SP2