What ever you decide to do it with, you better be maxed out with as much DR and DT as possible. DR is far more powerful, but a high DT will help. Buff out with all things like, Buff Out, Battle Brew, Med-X, Slasher, Large Wasteland Tequila, Wasteland Tequila, Weapon Binding Ritual, Yogi Meat...I know I am missing some...
Some of these things will add to your damage as well. Make sure you have all the needed perks as well. Unarmed has Pear Strike and Par Palm. Oh Baby is a strong melee. A chainsaw will negate the DT of a DC. Just holding that thing down on something, does massive damage. It will kill faster than the Threm Lance.
This is a pretty big task. It will take a well thought out Build / Chems / Perks / Meds to be successful.
Good Luck...You'll need it.