I mastered enchanting awhile ago with every single perk. I'm in the mid-50's levels and trying to master Alteration, just hit 90 skill with 2 perks chosen. I like telekinesis a lot, and plan to use it for thievery. Also plan to use water-breathing to explore the waters for hidden treasure.
I'm about to start the Alteration radiant quest at the college and am super excited to get the Paralysis and Mass Paralysis spells as well as Dragonskin. Throw in a flame atronoch or flame trap with my skill with a blade, and I can finally say my character is a true "Spellsword" character.