My vote is Speech. Like there is any shortage of expensive and sellable things in the game - there's no point in making things more valuable, because it just means more fast-traveling around to get (fairly useless) gold from vendors. Yeah, I know one can invest in the stores, but, it's easy to have 20 grand by level 10 with minimal effort.
Lockpicking is a close second, as one can pick a master lock with extremely low lockpicking, and lockpicks are everywhere.