I like the one in Windhelm, most storage and shelves, etc. Just wish that any of 'em had a mini-smelter and forge, sigh...
I still use the Whiterun house often however; it has a convenient central location and several vendors next door or very nearby.
Yeah, and the smithy next door, with smelter and 2 vendors to sell my stuff to, is great. But I wish they would've made the Whiterun home the largest and nicest one, since it's got the best location by far when travelling the world.