No specific one, but I hate how a lot of NPCs approach me and say stuff like "stop bothering me" or "i'm busy right now" or anything else to show me they don't want to deal with me right now. THEN WHY DO YOU EVEN TALK TO ME?! I could understand if I was trying to conversate with them, but I'm just standing there or talking to someone else.
This, more than anything.
"I work in (store), blah blah" as I'm running by. I tried to imagine doing this in RL, screaming, "I work for (company)" at people as they pass me. I'd have the cops on me.
"Don't bother me now, I'm busy." I'M NOT BOTHERING YOU. I am walking past you. Good god, man