Vault 22 took me forever the first time around (mainly because of the low repair skill).
Thats why I'm waiting before going there, with all the drugs/books I'm like 2 points short of repairing the I did Vault 11 last night, its probably one of my favourite vaults in the Mojave, I love listening to the holotape at the enterance and then figuring out the mystery behind it. I want to know what happened to the survivor