I walked the road from Solitute to Rifken going counter clockwise. I didn't stray onto side roads but I did clear out two of the dungeons that were on the main road, took note of others for later.
What a trip!
I must have been attacked by every type of man or beast, caught every disease at least once. Killed two dragons. Went up two levels. I didn't want to fast travel to dump loot so I only picked up the good stuff. I did get to sell it on the way though so I was never over loaded.
So... If you have nothing better to do, go for a walk.
I didn't go looking for trouble but I didn't avoid it.