C4 traps - of all my playthroughs - proved to be the most effective. I would sneak around until I saw a Deathclaw. Either climbing up a mining ramp (?) or just behind a rock, I would place C4 at the bottom of the ramp or somewhere on the direct line from me to the targeted Deathclaw. I'd shoot the Deathclaw once and then, boom; activate the detonator at the right moment and it's over. It was a ...blast.

Though usually, that works on only a couple before I have to resort to Chems n' Guns!

The first time a combination of a hunting rifle from far off until they closed the followed by the ranger sequoia. It was actually quite a rush since nothing had really been dangerous for some time with the setup I was using most enemies didn't even get close.

The deathclaw killer challenge from GRA was also quite fun nothing like paper cutting a deathclaw to death with a .22 even with 1 or 2 bars of health it takes way longer than you think it should.

I use ALIENS!

Gatling laser max charge ammo. Every dc in and around the quarry. Same thing with dead winds.

I just tried again with my NCR playthrough. I sniped the mother from the Khan camp with a guass rifle. A sneak critical was useful, I needed approx 2 more hits with the rifle, however I couldnt pick my shots right. 12 seconds later she one hitted me and I died

I run right in and onto the big crane, then jump onto either the sides of the rocks or the metal containers so I am out of reach of the Deathclaws, from there I can take pot shots and avoid major injury. Usually use Gobi/Holy Grenades/Annabelle and a Stealth boy to sneak round the mother and babies to collect the loot then I run like hell.

Went in there with mines... I used 4 plasma mines, 5 frag mines, and 2 stun mines to take out the mother death claw... For the Alpha deathclaw I shot him in the face until he died..... But in order to lure the mother deathclaw to where I was I sniped the baby death claws... Mama came at me, took her down...

Popped a lot of Chems, had the do 50% damage with Melee weapons to Deathclaws perk... marched into Quarry Junction with Gehenna and let them come at me. My 2 companions, Veronica (with Tri-Beam Laser Rifle) and ED-E reduced their HP enough, so by the time they reached me, I killed them with a few slashes! What a RUSH hahahaha

My first play through, I used Boone and ED-E and a rock and a sniper rifle.

Well I sniped them with the anti-material rifle on top of those high steps and put land mines at the bottom in case they came up after me, plus I had my campanion wait at the top of another set of steps and he shot at them too. Took about 30 min to get them all, lol.

Alien Blaster+Turbo

Alien Blaster, if I don't have that, then I save, run, get killed, save, run, take off clothes, run faster.

I like where this is going.

No need for alien blaster, a few holy frags and maybe a couple of mini nukes should do the trick.

LMG, all mods, AP rounds and a rock.
Used the AMR with AP rounds for the mother and Alpha DC's.