Thanks for the advice, sounds promising. Would I really need to reinstall the game? as the game is already installed on the hard drive which I am going to connect straight on. I figured that it would all stay as it was with even my current bash patch remaining.
Oh, if you're keeping your HDD, just make sure to regenerate renderinfo.txt and Oblivion.ini. Backup the latter so that you can do a diff with Notepad++ or some other text editor and redo the tweaks you'd like.
Just in case something happens when you try to refresh your Oblivion ini: http://tescosi.com/wiki/Oblivion.ini
Sounds like your games'll be just fine.
--Tomlong75210
Edit: If your old drive is going to be your secondary drive, then the paths for which the registry is aware will need to change. You should reinstall Oblivion. The page I linked with the reinstallation instructions has instructions for both moving Oblivion and reinstalling to the same location. Either way, you're going to need to rerun setup.exe this time. :L Same advice as before, backup Data, Oblivion.ini and Saves. Read Wrye Bash's readme for instructions on backing up BAIN, if you use it. You'll have to reinstall BOSS, Bash and OBMM for the same reason, registry needs to be aware of their locations.