I've been having some troubles on my main character in New Vegas. My character is level 50, max skills, and I was planning to complete everything I can before playing the final quest to end the game.

However, I've been held back by bugs. Whenever I open or switch between menus on the Pip-Boy, open containers of any sort, and other such things with menus, a small freeze/lag occurs. This may not seem that bad at first, but it quickly becomes annoying when you want to quickly switch between Pip-Boy screens or are in an area with lots of containers. It also takes a longer than usual time to load different areas, but that is more bearable to me.

Is this something that happens with large save files with no solution other than to just deal with it, or is there a way I can fix this?

Are you using mods? Using any menu mods? How big are your save files and how many saves do you have?

Might try disabling mods just to see if that is the culprit. It's possible you have too many items.

If you are using the "Revelation" mod, which changes the menu/barter/conversation windows, you will run into this.