Eeeh a little more info would help...
Did You use/try any of the following things:
Is your console on-line.. Did you download all the recent patches..?
Did you delete any DLC? (yes I know... mr. obvious)
Did you clear the cache...?
Did you try to delete all the DLC and then reinstall them..
Try another toon to see if there are any problems?
For the record... there will be no more patches.. The game has been finalized by Obsidian... so we have to troubleshoot..