Begin ScriptEffectStart
ForceAV fatigue -1000
End

If, while the game is running, I use command forceav fatigue -1000 on an actor they will keel over for a while and get back up when their fatigue regenerates.

But with that script on a spell they are down forever and don't regenerate fatigue.

Edit:
Nevermind. I just refreshed my memory on the construction kit wiki. I'll make it a timed effect and restore the fatigue on ScriptEffectFinish.

There's no need to use a script for this effect. Set up the spell with http://www.uesp.net/wiki/Oblivion:Drain_Fatigue for X seconds. The target's fatigue will be restored once the spell duration is up.

Yes, but it's hostile even though hostile is not checked. Probably because it is destruction. This is to get women out of the way, because no killing women in this playthrough unless a quest allows it. The character is female, I don't try to look at it as sixist. Those Aureal and Mazken [censored]es are always looking for someone to arrest and I hate that jail they send me to. It worked, set the timer for 2 minutes and it isn't hostile.