Something that might help is if Bethesda plans ahead.
Josh Sawyer cited knowing how many DLCs they were licensed for as being a huge advantage in their design. From the get-go, Bethesda promised them four DLCs, so they knew they'd have four no matter what, and that way, were able to plan for it, tie them all together, allow for NPCs to acknowledge content back and forth between the DLCs and the Mojave (Veronica, ED-E) etc etc.

I noticed another moral lesson in DM besides letting go, Treat others how you want to be treated, because if you're a dike to you're companions they'll end up betraying you, it took me two playthroughs to learn that one.

I hope this is how BGS plans on doing future DLCs, meaning they all tie together.
Sure, they could have released all the separate DLCs with no connection to one another, but having that small side story tie them all together was just icing on the cake.
It made finding things like Christines COS rifle so much more fun.
I do have to say, LR is quite confusing. This is my 3rd playthrough of it and I'm still confused as hell.
Specifically right when you get out of the collapsed tunnel, and you enter into a conversation with Ulysees(Through EDE). I literally had to reload to a save just before that conversation just to try n get a better grasp on WTF Ulysees is talking about. I made this road? I used to live here?
Talk about a brain [censored]. I guess alot of what he's saying is supposed to of happened prior to the events we see in game, it's still confusing as hell.