I always, always pick Sniper here, but I am trying something different this time around. Plus I am going to take Center Of Mass at lvl 14, so i'm not going to worry about my vats accuracy for head shots. So far I have taken:

2 - Intense Training
4 - Comprehension
6 - Shotgun Surgeon
8 - Grunt
10 - And Stay Back
12 - TBD

and these two are reserved for their respective levels
14- Center of Mass
16 Better critcals

just curious to what you guys and girls think. i'm tossing it up between Toughness (have a 22 DT currently), Strong Back (not really using housing this time around, and I can carry 240 right now) or maybe Bloody Mess to give the grunt weapons a bit more of a punch.

I've always felt that Educated is one of the best perks so you could try that. Hand Loader would go great with any Guns playthrough and Pack Rat is a given for a hardcoe playthrough. it all really depends on what type of character you have and what your skills and SPECIAL are.