I always use a customs keyset for FPS and usually don't have a problem. With Brink so far I'm seeing 2 problems:

1) Mouse-wheel down will not rebind. At least not to "melee attack".
2) Any key bound to the "Num Pad ENTER" won't work. Instead it reverts to the default enter key and does nothing.

If these 2 issues could be addressed I'd appreciate it. I can't get used to the game without my typical setup.

I noticed the same issue, I want to bind melee to the mouse wheel.

They are aware of this issue, expect it to be fixed in the next major patch.

Good to know, hopefully until then I don't get too accustomed to not having melee on the wheel.

i think they just use mousewheel as a toggle. it doesnt seem to have up/down. to be honest its a bit iffy as i use mousewheel button (press mousewheel) for handing out buffs etc